Recombinant Human Methionine Adenosyltransferase I, Alpha
供应商
ProSpec
产品货号
ENZ-493
产品报价
¥询价/10ug ¥1mg ¥2ug
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产品新闻
背景资料
MAT1A catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. MAT1A is found as a homotetramer(MAT I) or a homodimer(MAT III) whereas a third form, MAT II(gamma), is encoded by the MAT2A gene. Mutations in MAT1A gene are associated with methionine adenosyltransferase deficiency. MAT1A expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT2A present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NFkB and TNFa cause a switch from MAT1A to MAT2A expression in human hepatocellular carcinoma(HCC), which facilitates cancer cell growth.