Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VDVAD-pNA (for caspase-2) and DEVD-pNA (for caspase-3 & -7).
序列
活性的人Caspase套装组II蛋白产品,又称待更新.其对应NCBI基因号为CASP1- 834
CASP4- 837
CASP5 -838,NCBI基因别称为CASP1
CASP4
CASP5
;该基因种属来源为人源,对应Accession号为CASP1- NP_150634.1
CASP4- P49662
CASP5- P51878.该蛋白产品又称Active Human Caspases group, active human caspase, active caspases, human caspases, caspase enzyme, caspase protein等.
来源宿主
提供的【Caspases Group II】活性的人Caspase套装组II产品的来源为大肠杆菌中重组表达.