谷氨酸羧肽酶II抑制剂筛选试剂盒（荧光法）-Glutamate Carboxypeptidase II Inhibitor Screening Kit (Fluorometric)代理/参数/厂家-细胞分析试剂盒-开云·官方站线上登录平台入口

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细胞分析试剂盒

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中文名称: 谷氨酸羧肽酶II抑制剂筛选试剂盒（荧光法）

英文名字: Glutamate Carboxypeptidase II Inhibitor Screening Kit (Fluorometric)

供应商: Biovision

产品货号: K440-100

产品报价: ￥询价/100assays

产品说明书

购买方式: 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.

产品新闻

背景资料: 待更新

产品描述: Glutamate Carboxypeptidase II [GCPII, EC 3.4.17.21; N-acetylated-alpha-linked acidic dipeptidase (NAALADase), prostate-specific membrane antigen (PSMA) or folate hydrolase (FOLH1)] is a multifunctional zinc-metallopeptidase. Within the last decade, GCPII has been studied as a promising pharmacological target for the treatment of various pathological disorders and diseases and tremendous efforts have been made in order to discover potent GCPII inhibitors. NAALADase, the brain isozyme, plays an important role in Glutamate biosynthesis and could be used for treating neuronal damage caused by excess glutamate in brain. For example, inhibition of GCPII has shown neuroprotective characteristics in animal models suffering several acute and chronic conditions (stroke, neuropathic and inflammatory pain, schizophrenia, depression or amyotrophic lateral sclerosis). In males, PSMA is overexpressed in patients suffering prostate cancer and thus, it is used as a diagnostic marker for this disease. BioVision’s Glutamate Carboxypeptidase II Inhibitor Screening Kit is an in vitro tool in order to screen potential human GCPII inhibitors. The provided substrate is transaminated in the presence of GCPII producing glutamate. The detection system is based on an enzymatic reaction in which a fluorogenic probe is reduced generating a stable signal. In the presence of 2-PMPA, a potent GCPII Inhibitor, the enzymatic activity is arrested, thus generating lower fluorometric signal. The assay kit is a simple plate-based format and provides a rapid and reliable test for high-throughput screening of GCPII inhibitors.

产品特点: Includes Inhibitor Control (2-PMPA), Simple and reliable test to screen GCPII inhibitors/activators, High-throughput compatible

保存建议: -20

其他: BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.