Rabbit IgG polyclonal antibody for DLGAP1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for DLGAP1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: Rabbit IgG polyclonal antibody for DLGAP1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for DLGAP1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.

背景资料: Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic absorbance, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic absorbance also resets the synapse after each synaptic firing. It is composed of numerous proteins including a family of Discs large associated protein 1, 2, 3 and 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic absorbance. They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors, to signalling proteins and to components of the cytoskeleton. With the central localisation in the postsynapse, the DLGAP family seems to play a vital role in synaptic scaling by regulating the turnover of both ionotropic and metabotropic glutamate receptors in response to synaptic activity. DLGAP family has been directly linked to a variety of psychological and neurological disorders.

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