Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) detection. Tested with WB in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) detection. Tested with WB in Human;Mouse;Rat.代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) detection. Tested with WB in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 17(ADAM17) detection. Tested with WB in Human;Mouse;Rat.

背景资料: ADAM17(ADAM metallopeptidase domain 17), also called TACE (tumor necrosis factor-alpha-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha(TNF-alpha) at the surface of the cell, and from within theintracellular membranes of the trans-Golgi network. This process, which is also known as "shedding", involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins(such as pro-TNF-alpha), and is of known physiological importance. ADAM17 was the first "sheddase" to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules,receptors, ligands, and enzymes.

免疫原: A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM17(806-824aa AASFKLQRQNRVDSKETEC), different from the related rat and mouse sequences by one amino acid.

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