This gene encodes a member of the low absorbance lipoprotein receptor (LDLR) family. Low absorbance lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
应用类型
ELISA,FC,ICC,IF,IHC,WB
免疫原
E.coli-derived human ApoER2/LRP8 recombinant protein (Position: R444-D960).