Rabbit IgG polyclonal antibody for Bone morphogenetic protein receptor type-1B(BMPR1B) detection. Tested with WB in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for Bone morphogenetic protein receptor type-1B(BMPR1B) detection. Tested with WB in Human;Mouse;Rat.代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: Rabbit IgG polyclonal antibody for Bone morphogenetic protein receptor type-1B(BMPR1B) detection. Tested with WB in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for Bone morphogenetic protein receptor type-1B(BMPR1B) detection. Tested with WB in Human;Mouse;Rat.

背景资料: BMPR1B(Bone Morphogenetic Protein Receptor Type IB), also known as ALK6, is a protein which in humans is encoded by the BMPR1B gene. BMPR1B is a member of the bone morphogenetic protein(BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine(threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. By analysis of a monochromosome hybrid mapping panel and by FISH, Astrom et al.(1999) mapped the BMPR1B gene to chromosome 4q22-q24. Ide et al.(1997) compared BMP receptor expression in normal and cancerous prostate tissues. While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue.

免疫原: A synthetic peptide corresponding to a sequence in the middle region of human BMPR1B(145-160aa FCYFRYKRQETRPRYS), different from the related rat and mouse sequences by one amino acid.

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