用于开发夹心ELISA试剂盒，以测定细胞培养上清液、细胞裂解物、血清和血浆（肝素、EDTA）中的小鼠FGF21。-For the development of sandwich ELISA kit to measure mouse FGF21 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).代理/参数/厂家-ELISA试剂盒-开云·官方站线上登录平台入口

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ELISA试剂盒

开云·官方站线上登录平台入口_开云(中国)

英文名字: For the development of sandwich ELISA kit to measure mouse FGF21 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).

背景资料: Fibroblast growth factor 21 is a protein that in humans is encoded by the FGF21 gene. By genomic sequence analysis, Nishimura et al. (2000) identified the FGF21 gene within the 5-prime flanking region of the FUT1 gene on chromosome 19. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents.

产品描述: 成纤维细胞生长因子21是一种在人体中由FGF21基因编码的蛋白质。通过基因组序列分析，Nishimura et al.（2000）在19号染色体上FUT1基因的5引物侧翼区域内鉴定了FGF21基因。该基因编码的蛋白质是成纤维细胞生长因子（FGF）家族的成员。FGF家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物学过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。FGF21刺激脂肪细胞中的葡萄糖摄取，但不刺激其他类型的细胞。这种作用是胰岛素活性的附加作用。脂肪细胞的FGF21处理与FRS2的磷酸化有关，FRS2是一种连接FGF受体和Ras/MAP激酶途径的蛋白质。在ob/ob小鼠中注射FGF21导致脂肪组织中Glut1的增加。当FGF21在转基因小鼠中过表达时，FGF21还保护动物免于饮食诱导的肥胖，并且当给予糖尿病啮齿动物时，FGF21降低血糖和甘油三酯水平。

其他: Nordic BioSite(北欧生物) 总部位于瑞典，成立于1997年，旨在分销研究和诊断领域的高质量和创新产品。 Nordic BioSite 被公认为整个北欧生物医学研究和诊断产品领域的领导者。他们拥有超过570万种的产品组合，代理了遍布欧洲和美国的顶级生物试剂制造商，是欧洲知名的一站式生物试剂代理商。除了作为分销商之外，Nordic BioSite 还拥有不断增长的自产产品线——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自产产品线(共26W+产品)。Nordic BioSite的产品类型主要是抗体，蛋白和试剂盒，产品适用范围涵盖15个不同的物种(人，牛，犬，鲶鱼，鸡，海豚，马，猫，豚鼠，小鼠，绵羊，兔子，大鼠，猪和火鸡)，可为您提供一站式的生命科学研究解决方案~