For the development of sandwich ELISA kit to measure mouse CCL20/MIP-3 alpha in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).-For the development of sandwich ELISA kit to measure mouse CCL20/MIP-3 alpha in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).代理/参数/厂家-ELISA试剂盒-开云·官方站线上登录平台入口

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中文名称: For the development of sandwich ELISA kit to measure mouse CCL20/MIP-3 alpha in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).

英文名字: For the development of sandwich ELISA kit to measure mouse CCL20/MIP-3 alpha in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).

背景资料: Macrophage Inflammatory Protein 3alpha(MIP3alpha), also called Chemokine, cc motif, ligand 20(CCL20). The MIP-3alpha/CCL20 gene was cloned and sequenced, revealing a four exon, three intron structure, and was localized by FISH analysis to 2q35-q36. MIP3alpha is predominantly expressed in lymph nodes, appendix, PBL, fetal liver, fetal lung and several cell lines. MIP3alpha/CCL20 and its receptor CCR6 are markedly up-regulated in psoriasis, and they may play a role in the recruitment of T cells to lesional psoriatic skin. And Alanine MIP-3alpha and Serine MIP-3alpha, the two forms of MIP3alpha, that differ by one amino acid at the predicted signal peptide cleavage site. Both of them were chemically synthesized and tested for biological activity. And both flu antigen plus IL-2-activated CD4(+) and CD8(+) T lymphoblasts and cord blood-derived dendritic cells responded to Ser and Ala MIP-3alpha.

产品描述: 巨噬细胞炎性蛋白3 α（MIP 3 α），也称为趋化因子，cc基序，配体20（CCL 20）。克隆MIP-3 α/CCL 20基因并测序，揭示了4个外显子、3个内含子的结构，并通过FISH分析定位于2 q35-q36。MIP 3 α主要在淋巴结、阑尾、PBL、胎儿肝、胎儿肺和几种细胞系中表达。MIP 3 α/CCL 20及其受体CCR 6在银屑病中显著上调，它们可能在T细胞募集至银屑病皮损中发挥作用。以及丙氨酸MIP-3 α和丝氨酸MIP-3 α，它们是MIP-3 α的两种形式，在预测的信号肽切割位点上相差一个氨基酸。这两种化合物都是化学合成的，并进行了生物活性测试。流感抗原加IL-2活化的CD 4（+）和CD 8（+）T淋巴母细胞和脐血来源的树突状细胞对Ser和Ala MIP-3 α均有应答。

其他: Nordic BioSite(北欧生物) 总部位于瑞典，成立于1997年，旨在分销研究和诊断领域的高质量和创新产品。 Nordic BioSite 被公认为整个北欧生物医学研究和诊断产品领域的领导者。他们拥有超过570万种的产品组合，代理了遍布欧洲和美国的顶级生物试剂制造商，是欧洲知名的一站式生物试剂代理商。除了作为分销商之外，Nordic BioSite 还拥有不断增长的自产产品线——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自产产品线(共26W+产品)。Nordic BioSite的产品类型主要是抗体，蛋白和试剂盒，产品适用范围涵盖15个不同的物种(人，牛，犬，鲶鱼，鸡，海豚，马，猫，豚鼠，小鼠，绵羊，兔子，大鼠，猪和火鸡)，可为您提供一站式的生命科学研究解决方案~