Human CellExp™ Integrin alpha V beta 8, Human recombinant
供应商
Biovision
产品货号
P1122-50
产品报价
¥已停产
产品说明书
购买方式
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产品新闻
背景资料
Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
序列
提供的Human CellExp™整合素alpha V beta 8,人类重组Human CellExp™ Integrin alpha V beta 8, Human recombinant是Biovision品牌中国区域总代理艾美捷科技产品,具体的蛋白序列可查看提供的英文版本产品说明书。
来源宿主
提供的Human CellExp™整合素alpha V beta 8,人类重组Human CellExp™ Integrin alpha V beta 8, Human recombinant产品来源宿主,查看该产品说明书,或者在线咨询我们。
溶解建议
Reconstitute in sterile deionized water to the desired protein concentration.
保存建议
在您收到艾美捷发出的Human CellExp™整合素alpha V beta 8,人类重组产品后,建议将其置于-20ºC保存。