ST3Gal1 catalyzes transfer of the sialic acid Neu5Ac from CMP-Neu5Ac (cytidine 5'-monophosphono-N-acetylneuraminic acid) to Galβ1, 3GalNAc on glycoproteins or glycolipids in an α2, 3 linkage. It is a type II transmembrane protein that is normally localized to the golgi, but can be cleaved to yield a soluble product. Sialylation of the core-1 structure (Galβ1, 3GalNAc-O-Ser/Thr) by ST3Gal1 prevents formation of the core-2 structure (GlcNAcβ1, 6(Galβ1, 3)GalNAc-Ser/Thr). On CD8+ T-cells this prevents induction of either apoptosis or differentiation into memory cells. Overexpression of ST3Gal1 in breast cancer cells correlated with the presence of the core-1 based marker SM3, whereas healthy cells displayed a higher ratio of core-2 based epitopes. Overexpression of ST3Gal1 in colorectal carcinoma was found to be related to poor patient survival.
序列
提供的ST3Gal1,可溶性片段,人类重组ST3Gal1, soluble fragment, Human Recombinant是Biovision品牌中国区域总代理艾美捷科技产品,具体的蛋白序列可查看提供的英文版本产品说明书。
来源宿主
提供的ST3Gal1,可溶性片段,人类重组ST3Gal1, soluble fragment, Human Recombinant产品来源宿主,查看该产品说明书,或者在线咨询我们。
溶解建议
该ST3Gal1,可溶性片段,人类重组ST3Gal1, soluble fragment, Human Recombinant产品的溶解建议详情请查阅产品说明书。