Siglec-15 is a transmembrane glycoprotein of the siglecs family that participates in the immune regulatory systems through the recognition of their glycan ligands. Siglecs, short for sialic acid-binding immunoglobulin (Ig)-like lectins, are primarily expressed on the surface of immune cells and differentially control innate and adaptive immune responses. Mature human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD, Phe20 - Thr263) with two Ig-like domains, a 21 aa transmembrane segment (264-284), and a 44 aa cytoplasmic domain (285-328). Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemia, and ability to modulate receptor signaling. Because Siglec-15 is critical for proper development and function of osteoclasts, anti-Siglec-15 antibodies have therapeutic potential for treatment of osteoporosis.
序列
提供的Human CellExp™Siglec-15,人类重组Human CellExp™ Siglec-15, Human Recombinant是Biovision品牌中国区域总代理艾美捷科技产品,具体的蛋白序列可查看提供的英文版本产品说明书。
来源宿主
提供的Human CellExp™Siglec-15,人类重组Human CellExp™ Siglec-15, Human Recombinant产品来源宿主,查看该产品说明书,或者在线咨询我们。
溶解建议
Reconstitute in sterile PBS, pH 7.4 up to 0.2µg/µl.