Recombinant Human Toll-Like Receptor Adaptor Molecule 2
供应商
ProSpec
产品货号
PRO-1036
产品报价
¥询价/10ug ¥1mg ¥2ug
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产品新闻
背景资料
TICAM2 belongs to the Toll/interleukin-1 receptor (TIR) family, a group of proteins which include the Toll-like receptors (TLRs). TICAM2, a cytoplasmic protein, physically bonds TLR4 and TICAM-1 and functionally transfers LPS-TLR4 signaling to TICAM-1, that sequentially activates IRF-3. TICAM2 takes part in IL1-triggered NF-kappa-B activation, operating upstream of IRAK1, IRAK2, TRAF6, and IKBKB.