Recombinant Human Breast Carcinoma Amplified Sequence 2
供应商
ProSpec
产品货号
PRO-116
产品报价
¥询价/1ug ¥50ug ¥5ug
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产品新闻
背景资料
Pre-mRNA-splicing factor SPF27 (BCAS2) is a ubiquitously expressed nuclear protein that was initially identified as being overexpressed in various breast cancer cell lines. BCAS2 is currently as a component of the spliceosome, participating in the exclusion of introns from mRNA precursors. BCAS2 interacts in a ligand-independent manner particularly with Thyroid Hormone Receptor ? (TR?), Estrogen Receptor ? (ER?), ER?, Progesterone Receptor (PR) and Peroxisome Proliferator-activated receptor ? (PPAR?). BCAS2 acts as an ER co-activator and is capable of boosting ER-mediated transcription, suggesting that BCAS2 is involved in the development of breast cancer.