【rmS100b】重组猕猴S100钙粘结蛋白B-Recombinant Rhesus Macaque S100 Calcium Binding Protein B代理/参数/厂家-蛋白标准品-开云·官方站线上登录平台入口

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背景资料: S100b is a member of the S100 family of proteins which are a family of EF-hand calcium binding proteins that exist mostly as dimers of the 20 currently identified individual S100 monomers. The S100B homodimer is expressed in cells of the central nervous system， glial cells and in certain peripheral cells e.g. Schwann cells， melanocytes， adipocytes and chondrocytes. S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. There are at least 13 members in the S100 gene family， which are located as a cluster on chromosome 1q21； however， S100b is located at 21q22.3. The determination of S100B in serum levels may be used to monitor the extent of brain injury and malignant melanoma. S100b proteins may have a role in Neurite extension， proliferation of melanoma cells， stimulation of Ca2+ fluxes， inhibition of PKC-mediated phosphorylation， astrocytosis and axonal proliferation， and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of the S100b gene are implicated in several neurological， neoplastic， and other types of diseases， including Alzheimer’s disease， Down’s syndrome， epilepsy， amyotrophic lateral sclerosis， melanoma， and type I diabetes.

溶解建议: 提供的重组猕猴S100钙粘合蛋白B产品形式为冻干粉末.建议用无菌处理的18M-cm水溶解重组猕猴S100钙粘合蛋白B，浓度不低于100ug/ml.后继实验过程中可根据实验要求进一步稀释.

其他: ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。