Recombinant Human Immunity-Related GTPase Family, M
供应商
ProSpec
产品货号
PRO-1302
产品报价
¥询价/1mg ¥20ug ¥5ug
产品说明书
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产品新闻
背景资料
Immunity-related GTPase family M protein (IRGM) is essential for clearance of severe protozoan and bacterial infections. IRGM belongs to the p47 immunity-related GTPase family. IRGM serves in innate immune response possibly via regulation of autophagy. IRGM regulates proinflammatory cytokine production and inhibit endotoxemia upon infection and also has a part in macrophages adhesion and motility. Polymorphisms which modify the natural expression of the IRGM gene are associated with a susceptibility to Crohn’s disease and tuberculosis.