Recombinant Human Eukaryotic Translation Initiation Factor 2B Subunit 1 Alpha
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ProSpec
产品货号
PRO-209
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¥询价/1ug ¥50ug ¥5ug
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背景资料
EIF2B1 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), which is a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Phosphorylation of eIF2 inhibits GEF activity of EIF2B, an inhibition which requires the eIF2B1 subunit. Defects in eIF2B1 are a cause of leukoencephalopathy with vanishing white matter (VWM), a brain disease which is characterized by head trauma and motor deterioration.