中文名称

【PGP9.5 GST】重组人泛素C末端重组酶L1，GST标签

英文名字

Recombinant Human Ubiquitin Carboxyl-Terminal Hydrolase L1 GST tag

供应商

ProSpec

产品货号

PRO-304

产品报价

￥已停产

产品说明书

购买方式

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产品新闻

背景资料

UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein， structurally and immunologically distinct from neuron specific enolase. Human UCHL1 and UCHL3 have an extremely complicated knot structure for a protein， with five knot crossings. It is considered that the knot structure may increase a protein’s resistance to degradation in the proteasome.
The protein， which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons and nerve fibers at all levels of the central and peripheral nervous system， in many neurodcrine cells， in segments of the renal tubules， in spermatogonia and leydig cells of the testis， in ova and in some cells of both the pregnant and non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson’s disease in one kindred. On the other hand， a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson’s disease. Furthermore， UCHL1 is associated with the Alzheimer’s disease， and required for normal synaptic and cognitive function.

序列

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来源宿主

大肠杆菌中重组表达

溶解建议

Sterile Filtered clear solution. PGP9.5 at 0.1mg/ml in 50mM Tris-Acetate， pH7.5， 1mM EDTA， 20% Glycerol.

保存建议

Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

注意

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