Recombinant Human Small Ubiquitin-Related Modifier 2
供应商
ProSpec
产品货号
PRO-586
产品报价
¥询价/10ug ¥1mg ¥50ug
产品说明书
购买方式
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产品新闻
背景资料
Small Ubiquitin-like Modifiers (SUMOs) are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. Unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. All SUMO proteins share the conserved ubiquitin domain and the C-terminal diglycine cleavage/attachment site. Human SUMO2, also known as Sentrin2 and SMT3B is synthesized as a 95 amino acid (aa), 11 kDa propeptide that contains a two aa C-terminal prosegment, and an 18 aa N-terminal protein interacting region (aa 33 -50). Following prosegment cleavage, the C-terminal glycine is enzymatically attached to a lysine on a target protein. Human SUMO2 shares 100% sequence identity to SUMO-2 from mouse. SUMO2 also has very high sequence homology to SUMO3 and SUMO4, 86 % and 85%, respectively. SUMO2 shares only 44% sequence identity to SUMO1.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The SUMO2 containing 20 mM Tris-HCl buffer (pH 8.0)
保存建议
Can be stored at +4C for 1 week. For long term storage , below -20?C.
Please prevent freeze-thaw cycles.