Recombinant Human Baculoviral IAP Repeat-Containing 7
供应商
ProSpec
产品货号
PRO-612
产品报价
¥询价/1mg ¥20ug ¥5ug
产品说明书
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产品新闻
背景资料
BIRC7 is a part of the inhibitor of apoptosis protein (IAP) family and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is necessary for inhibitory activity & cooperates with caspases, while the RING finger domain sometimes increases anti-apoptotic activity but doesn’t inhibit apoptosis by itself. 2 transcript variants encoding diverse isoforms have been found for this gene. The 2 isoforms have dissimilar antiapoptotic characteristics, with isoform ? protecting cells from apoptosis induced by staurosporine and isoform b defending cells from apoptosis induced by etoposide.
BIRC7 has direct contact with several caspases together with caspase-3, caspase-7, & caspase –9. BIRC7 inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The BIRC7 solution contains 20mM Tris pH-8, 1mM DTT, 0.1M NaCl, 2mM EDTA and 20% glycerol.
保存建议
BIRC7 although stable 4℃ for 4 weeks, should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.