中文名称

【CRABP1】重组人胞内维甲酸结合蛋白-1

英文名字

Recombinant Human Cellular Retinoic Acid Binding Protein 1

供应商

ProSpec

产品货号

PRO-710

产品报价

￥询价/1mg   ￥20ug   ￥5ug

产品说明书

购买方式

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产品新闻

背景资料

CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though， CRABP1 is structurally similar to the cellular retinol-binding proteins， it binds only retinoic acid at specific sites within the nucleus， which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior.
Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore， frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma.

序列

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来源宿主

大肠杆菌中重组表达

溶解建议

Sterile Filtered colorless solution. The CRABP1 protein solution contains 20mM Tris-HCl buffer （pH8.0） and 10% glycerol.

保存建议

CRABP1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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