CFHR5 is a member of a small complement factor H (CFH)ngene cluster on chromosome 1. Each member of this gene familyncontains multiple short consensus repeats (SCRs) typical ofnregulators of complement activation. The protein encoded by thisngene has nine SCRs with the first two repeats having heparinnbinding properties, a region within repeats 5-7 having heparinnbinding and C reactive protein binding properties, and thenC-terminal repeats being similar to a complement component 3 bn(C3b) binding domain. This protein co-localizes with C3, binds C3bnin a dose-dependent manner, and is recruited to tissues damaged bynC-reactive protein. Allelic variations in this gene have beennassociated, but not causally linked, with two different forms ofnkidney disease: membranoproliferative glomerulonephritis type IIn(MPGNII) and hemolytic uraemic syndrome (HUS). [provided bynRefSeq].
应用类型
WB, IHC-P, Flow
免疫原
This CFHR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the Central region of human CFHR5.
来源宿主
兔
反应性
人
保存建议
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.