CALR 抗体-CALR Antibody代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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中文名称: CALR 抗体

英文名字: CALR Antibody

供应商: ProSci

产品货号: PSI-62-527

产品报价: ￥询价/400ul

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背景资料: Calreticulin is a multifunctional protein that acts as anmajor Ca(2+)-binding (storage) protein in the lumen of thenendoplasmic reticulum. It is also found in the nucleus, suggestingnthat it may have a role in transcription regulation. Calreticulinnbinds to the synthetic peptide KLGFFKR, which is almost identicalnto an amino acid sequence in the DNA-binding domain of thensuperfamily of nuclear receptors. Calreticulin binds to antibodiesnin certain sera of systemic lupus and Sjogren patients whichncontain anti-Ro/SSA antibodies, it is highly conserved amongnspecies, and it is located in the endoplasmic and sarcoplasmicnreticulum where it may bind calcium. The amino terminus ofncalreticulin interacts with the DNA-binding domain of thenglucocorticoid receptor and prevents the receptor from binding tonits specific glucocorticoid response element. Calreticulin canninhibit the binding of androgen receptor to its hormone-responsivenDNA element and can inhibit androgen receptor and retinoic acidnreceptor transcriptional activities in vivo, as well as retinoicnacid-induced neuronal differentiation. Thus, calreticulin can actnas an important modulator of the regulation of gene transcriptionnby nuclear hormone receptors. Systemic lupus erythematosus isnassociated with increased autoantibody titers against calreticulinnbut calreticulin is not a Ro/SS-A antigen. Earlier papers referrednto calreticulin as an Ro/SS-A antigen but this was later disproven.nIncreased autoantibody titer against human calreticulin is found inninfants with complete congenital heart block of both the IgG andnIgM classes.

应用类型: WB, IHC-P, Flow

免疫原: This CALR Antibody is generated from rabbits immunized with a recombinant protein of human CALR.

来源宿主: 兔

反应性: 人, 大鼠

保存建议: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

其他: ProSci Incorporated于1998年成立于美国加州圣地亚哥市,从事抗体等科研试剂的研发、生产和销售。产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci拥有超过30000种单克隆抗体和多克隆抗体。ProSci的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。