FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
DISEASE: Defects in HRAS are also the cause of oral squamous cell carcinomas (OSCC).
PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
ENZYME REGULATION: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
应用类型
WB
免疫原
116-189
来源宿主
鸡
反应性
小鼠, 大鼠
保存建议
HRAS antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.