FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity.
SIMILARITY: Belongs to the Ser/Thr protein kinase family. MAP kinase kinase subfamily.
应用类型
WB
免疫原
1-28
来源宿主
鸡
反应性
人, 小鼠, 大鼠
保存建议
MAP2K1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.