FUNCTION: May act as a B cell-associated adapter that regulates B cell antigen receptor (BCR)-signaling downstream of PI3K.
SUBUNIT: Interacts with PtdIns(3,4,5)P3 and PLCG2. in vitro, interacts with PtdIns(3,4)P2.
PTM: Phosphorylated on tyrosine residues.
SIMILARITY: Contains 1 SH2 domain.
SUBCELLULAR LOCATION: Cytoplasmic and membrane-associated after cell stimulation leading to its translocation.
TISSUE SPECIFICITY: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B lymphocytes, but not T-lymphocytes or nonhematopoietic cells.
应用类型
WB
免疫原
119-164
来源宿主
鸡
反应性
人
保存建议
DAPP1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.