p38 抗体-p38 Antibody: Dylight 594代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: p38 抗体

英文名字: p38 Antibody: Dylight 594

供应商: StressMarq

产品货号: SPC-172D-DY594

产品报价: ￥已停产

产品说明书

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产品新闻

背景资料: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2A translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 A has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).

应用类型: WB | IHC | ICC/IF | IP

免疫原: 加了半胱氨酸的人 p38合成肽, 长20 AA, 钥孔虫戚血蓝素螯合.

来源宿主: 兔

反应性: 人 | 小鼠 | 大鼠 | 牛 | 猴 | 兔 | 猪 | 狗 | 仓鼠 | 鸡 | 绵羊 | 豚鼠

保存建议: 厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。

其他: StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍及3135多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与A-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，Str