This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.
应用类型
WB
免疫原
CIDEA
来源宿主
兔
反应性
人
保存建议
建议收到该Cell Death Activator CIDE-A (CIDEA) Antibody产品后,储存温度为-20°C。避免重复冻融