Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) Antibody-Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) Antibody代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

保存建议: 建议收到该Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) Antibody产品后，储存温度为-20°C。避免重复冻融

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