扎伊尔埃博拉病毒 GP 蛋白兔多克隆抗体-Rabbit polyclonal antibody to Zaire Ebolavirus GP protein代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: 扎伊尔埃博拉病毒 GP 蛋白兔多克隆抗体

英文名字: Rabbit polyclonal antibody to Zaire Ebolavirus GP protein

供应商: Icosagen

产品货号: A2-100-100

产品报价: ￥询价/100ug ￥500ug ￥1mg

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产品新闻

背景资料: GP1 is responsible for binding to the receptors on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). GP2 acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. Mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates integrins ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. GP1,2 alters the cellular recycling of the dimer alpha-V/beta-3 via a dynamin-dependent pathway. Decrease in the host cell surface expression of various adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during Ebola virus infection (cytotoxicity). (Ebola GP1 and 2 functions, UniProt).

应用类型: ELISA, WB, IF

免疫原: Ebolavirus GP protein

来源宿主: 兔

反应性: Zaire Ebolavirus GP protein

保存建议: Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use.

其他: Icosagen AS成立于1999年，总部位于爱沙尼亚，提供一系列现成产品，如抗体、蛋白质、ELISA试剂盒等，以及天然橡胶过敏原检测和食品质量控制领域的质量控制服务。产品涵盖的应用领域有：神经生物学，病毒学，心脏标志物，细胞因子，炎症，过敏原等。Icosagen提供用于诊断和研究的重组抗体和抗原。Icosagen将现代重组技术和20年的制药经验引入诊断领域，以开发和生产高质量的试剂。利用Icosagen的专利系列，开发和生产高亲和力和特异性的单克隆和多克隆抗体。Icosagen已通过ISO 9001:2015认证，并遵循GLP指南。