Recombinant Human Glial-Derived Neurotrophic Factor
供应商
ProSpec
产品货号
CYT-305
产品报价
¥询价/10ug ¥1mg ¥2ug
产品说明书
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产品新闻
背景资料
GDNF promotes the survival and differentiation of dopaminergic neurons in culture,and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF,two additional alternative transcripts encoding distinct proteins,referred to as astrocyte-derived trophic factors,have also been described. Mutations in this gene may be associated with Hirschsprung disease.
GDNF enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.